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Migraine pathophysiology is associated with activation of the trigeminovascular system, CGRP release and cranial vasodilatation. Triptans are 5‐HT1B/1D/(1F) receptor agonists with vasoconstrictive e ...


A novel approach to immunotherapy developed by researchers at the National Cancer Institute ( NCI ) has led to the complete regression of breast cancer in a patient who was unresponsive to all other t ...


The PI3K/AKT/mTOR pathway is an intracellular signalling pathway that regulates cell activation, proliferation, metabolism and apoptosis. Increasing body of data suggests that alterations in the PI3K/ ...


Aging is associated with an increased incidence of cancer and cardiovascular disease. Researchers recently used whole-exome sequencing data to identify a common, age-related disorder marked by an expa ...


Chromosomal translocations that generate in-frame oncogenic gene fusions are notable examples of the success of targeted cancer therapies. Gene fusions of FGFR3-TACC3 ( F3–T3 ) had been previously ...


A research has shown the Parkinson's disease drug Carbidopa displays significant anticancer effects in both human cell lines and mice when given at normal patient dosage levels. This discovery, whi ...


Researchers at the Ruhr-Universität Bochum's burn unit ( Germany ) and the Center for Regenerative Medicine at the University of Modena ( Italy ) were the first ever to successfully treat a child suff ...


The FDA ( Food and Drug Administration ) has approved Yescarta ( Axicabtagene ciloleucel ), a cell-based gene therapy, to treat adult patients with certain types of large B-cell lymphoma who have not ...


Chimeric antigen receptor ( CAR ) T cell immunotherapy has demonstrated profound results in hematologic malignancies but clinical efficacy in the solid tumor setting has not been observed. Barriers t ...


A study has demonstrated the first successful utilization of a photosynthetic system as a means of correcting tissue ischemia. The Synechococcus elongatus ( S. elongatus ) use interstitial H2O and C ...


Inflammation plays a considerable role in the progression of Duchenne muscular dystrophy ( DMD ), a severe muscle disease caused by a mutation in the dystrophin gene. Researchers previously showed ...


Researchers at UT Southwestern Medical Center have identified a protein termed ASCL1 that is essential to the development of small cell lung cancer and that, when deleted in the lungs of mice, prevent ...


City of Hope researchers at Duarte, California ( U.S. ) have reported on the successful treatment of a patient with recurrent multifocal glioblastoma using CAR-T therapy, a type of immunotherapy, to e ...


Deregulation and inhibition of the immune system contributes to cancer development. Many therapeutic strategies aim to re-stimulate the immune system to recognize cancer cells and target them for dest ...


The functional aspects of programmed death 1 ( PD-1 ) and PD ligand 1 ( PD-L1 ) immune checkpoints in malignant mesothelioma have not been studied. Tumor samples from 65 patients with mesothelioma ...