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Researchers from Memorial Sloan Kettering Cancer Center have reported more encouraging news about one of the most exciting methods of cancer treatment today. The largest clinical study ever conducted ...


Researchers at the University of Illinois at Chicago have developed a system for precisely delivering anti-inflammatory drugs to immune cells gone out of control, while sparing their well-behaved coun ...


The immune system wages an internal battle every day to protect people against a broad range of infections. However, researchers have found that the immune response can sometimes make us vulnerable to ...


Previous studies have demonstrated that less-differentiated T cells are ideal for adoptive T cell transfer therapy ( ACT ) and that fibronectin CH296 ( FN-CH296 ) together with anti-CD3 resulted in cu ...


Several organs, including the lungs and kidneys, are formed by epithelial tubes whose proper morphogenesis ensures correct function. This is best exemplified by the kidney, where defective establishme ...


Hypertension and chronic kidney disease ( CKD ) are complex traits representing major global health problems. Multiple genome-wide association studies have identified common variants in the promoter o ...


In humans, mutations in the gene encoding for forkhead box P3 ( FOXP3 ), a critically important transcription factor for CD4+CD25+ regulatory T ( Treg ) cell function, lead to a life-threatening syste ...


The immune system is composed of numerous interacting cell populations with distinct functions. As for any system, it is ( it has to be ) tightly regulated. Failure of regulation leads notably to infl ...


Recessive dystrophic epidermolysis bullosa ( RDEB ) results from deficiency of type VII collagen ( C7 ), which results in lack of attachment between the epidermis and dermis, severe blistering, and a ...


The Committee for Medicinal Products for Human Use ( CHMP ) has recommended marketing authorisation for Maci ( matrix-induced autologous chondrocyte implantation ), an advanced-therapy medicinal produ ...


A study has identified a previously unrecognized mutation that causes an inherited form of amyotrophic lateral sclerosis ( ALS ). The research, published in the journal Neuron, implicates defects in ...


Genetic variations in the Sonic Hedgehog pathway increase the likelihood of recurrence, reduce survival time and limit response to therapy for people with non-muscle invasive bladder cancer.These vari ...


The first operation for transplantation of a tissue-engineered airway has been successful, and has massively improved the quality of life of the 30-year-old Colombian female recipient, a mother of two ...


The FDA ( Food and Drug Administration ) has approved a drug to help ease the suffering faced by those with certain chronic inflammatory diseases. Arcalyst ( Rilonacept, an Interleukin-1 blocker ) is ...


A gene therapy treatment that restores a missing liver enzyme in test animals could provide a cure for a rare metabolic disorder in humans. People born with the disorder, called glycogen storage ...